FANDOM


Nchembio.416-F1

Liu et al., 2010: Replication-dependent instability at (CTG)•(CAG) repeat hairpins in human cells

Trinucleotide repeats are very common and widely spread throughout the human genome. They can be found inside introns or even inside open reading frames (exones, in translated and untranslated regions). They can be very unstable and cause expansions or deletions during DNA replication. Expansions occur during replication of the lagging strand, when a hairpin- formed by the trinucleotide repeat-is present at an Okazaki fragment. The presence of the hairpin on a template strand mainly leads to deletions. Trinucleotide repeat expansions are a couse of many diseases, known as trinucleotide expansion diseases, such as the fragile X syndrome (CGG), Huntington's disease (CAG) or Myotonic distrophy (CTG).

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.