Matters arisingEdit

Lisz and Rachael expect to be absent today

Presentation of genome projectsEdit

  1. Students who have not yet presented
  2. Students who have added further content since last class

Web site evaluation:Edit

Faculty of 1000

Wiki contributionsEdit

Assignments for next class (Wed 13 Nov)Edit

(1) Finish Exercises, problems and weblems for chapters 6 and 7

(2) Read Lesk Chapter 5: Evolution and Genomic Change

(3) Exercises, problems and weblems for chapter 5

(4) Download. read and come to Wed class prepared to discuss the following paper:

PDF is available here

Fleischmann RD et al. 1995. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science.1995 Jul 28;269(5223):496-512. An approach for genome analysis based on sequencing and assembly of unselected pieces of DNA from the whole chromosome has been applied to obtain the complete nucleotide sequence (1,830,137 base pairs) of the genome from the bacterium Haemophilus influenzae Rd. This approach eliminates the need for initial mapping efforts and is therefore applicable to the vast array of microbial species for which genome maps are unavailable. The H. influenzae Rd genome sequence (Genome Sequence DataBase accession number L42023) represents the only complete genome sequence from a free-living organism.

PMID 7542800 [PubMed - indexed for MEDLINE]

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